It's a year of bold new beginnings as your favorite doctors return to Seattle Grace for the biggest challenge of their lives. The plane crash that took the lives of Lexie Grey and Mark Sloan sent shockwaves throughout the hospital. But from the ashes, romance will rise, with each surgeon handling the loss in their own personal way. Meredith finds her groove in the operating room while Derek's hand injury forces him to focus on something other than surgery. And as Mark prepares to say goodbye, Alex falls for someone new, Cristina tries to rekindle the flame with Owen, and Bailey and Ben discover the perils of a long-distance relationship.